BloodTestEasy

MCHC 37.3 g/dL

= 373 g/L in SI units

High

Consider discussing this with your doctor in the coming weeks.

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  • Severely low
  • Markedly low
  • Low
  • Borderline low
  • Normal
  • Borderline high
  • High

At a glance

Your band
High · 37–38 g/dL
Distance from typical range
1.3 g/dL above 36.0
SI units
37.3 g/dL = 373 g/L

What 37.3 g/dL means

An MCHC of 37.3 g/dL is above what red blood cells can physically sustain in most people, so it usually signals either a red-cell disorder or a problem with the blood sample itself.

True MCHC values rarely exceed about 37 g/dL, so labs treat readings here with suspicion. Very often the cause is an artifact: cold agglutinin antibodies clumping cells, fatty (lipemic) blood, or red cells that broke apart in the collection tube. When the elevation is real, the usual culprits are hereditary spherocytosis or autoimmune hemolytic anemia — conditions where red cells are being reshaped or destroyed — and both deserve evaluation without long delay.

Most US labs consider roughly 32 to 36 g/dL normal for adult MCHC, following the convention cited by MedlinePlus, though your lab's printed range may differ slightly. There is no standard 'panic' cutoff for MCHC itself — with very abnormal values, the accompanying hemoglobin determines true urgency.

Common causes

  • Cold agglutinins — antibodies that clump red cells and confuse the analyzer
  • Lipemia (high fat levels in the blood sample)
  • Red cells rupturing in the tube during a difficult draw or rough handling
  • Hereditary spherocytosis
  • Autoimmune hemolytic anemia
  • Severe burns, which can create sphere-shaped red cells
  • A very high white blood cell count interfering with the measurement

Symptoms that can go with it

  • Often none, especially when the reading is a sample artifact
  • Fatigue or weakness
  • Yellowing of the skin or eyes (jaundice)
  • Dark, tea-colored urine
  • Fullness or discomfort under the left ribs (enlarged spleen)

Sensible next steps

  1. Contact your clinician within the next few days to arrange a repeat CBC — labs can rerun the sample warmed or with the plasma replaced to rule out artifacts
  2. If the repeat is still high, ask about tests for red-cell destruction: reticulocyte count, bilirubin, LDH, and haptoglobin
  3. Seek care promptly rather than waiting if you notice jaundice, dark urine, or sudden unusual fatigue
  4. Mention any family history of spherocytosis, anemia, or early gallstones
  5. Go over all results with your clinician before drawing conclusions — a single high MCHC is very often a sample issue, not a disease

Frequently asked questions

Is 37.3 g/dL a normal MCHC level?

No — 37.3 g/dL is above the typical adult range of 32–36 g/dL and above what red cells can usually sustain. That said, readings at this level are very often caused by sample artifacts rather than illness, so the first step is a repeat test arranged with your clinician soon.

What does a low MCHC mean?

A low MCHC means your red blood cells contain a lower-than-normal concentration of hemoglobin, making them look pale under a microscope — doctors call this hypochromia. The most common cause by far is iron deficiency; inherited conditions such as thalassemia trait and long-term inflammation are other frequent explanations. Your clinician will read it alongside hemoglobin, MCV, and often iron studies to pin down the cause.

What causes a high MCHC?

A value of 37.3 g/dL exceeds what red cells normally sustain, so the lab and your clinician will first want to exclude artifacts — cold agglutinins, lipemia, or in-tube hemolysis. If a repeat test confirms it, the main real causes to investigate are hereditary spherocytosis and autoimmune hemolytic anemia.

Can diet or iron pills fix a low MCHC?

Only if low iron is actually the cause — and that's a real 'if.' When iron deficiency is confirmed, iron-rich foods and supplements prescribed by your clinician usually normalize MCHC over a few months. But if the cause is thalassemia trait, extra iron won't help and can even be harmful, and if the iron deficiency comes from hidden blood loss, the bleeding source needs finding. Get iron studies done before starting supplements, and take them under a clinician's guidance.

Do I need to worry about an MCHC of 37.3 g/dL?

Concern should be measured, not alarmed. A value of 37.3 g/dL is most often a sample artifact, but because real elevations can reflect red-cell destruction or hereditary spherocytosis, contact your clinician within a few days for a repeat test — and promptly if you notice jaundice or dark urine.

What is the difference between MCHC, MCH, and hemoglobin?

Hemoglobin is the total amount of the oxygen-carrying protein in your blood — the headline anemia number. MCH is the average amount (weight) of hemoglobin inside a single red cell, while MCHC is the average concentration — how tightly that hemoglobin is packed relative to the cell's size. Two people can have identical hemoglobin but different MCHC values if their red cells differ in size and density, which is exactly why doctors use these indices to sort out what type of anemia is present.

Check a different MCHC value

Sources

Educational information, not medical advice. Reference ranges vary between labs — always compare with the range printed on your own report and discuss results with your doctor. Full disclaimer